In that interview he commented:
"With No More Heroes 1, the idea came when I was literally sitting on the toilet. It was the result of trying to empty my bowels, if you like."Sounds like the mindset of the guy that brought us the outlandish playstyle and ideas that NMH 1 & 2 have. Still, if he and his team at Grasshopper Manufacture can keep the crazyness coming with a 3rd title in the series (if there will be one) then so be. Just keep the toilet references to saving or the bathroom, thank you.
"With No More Heroes 2, I tried to get rid of whatever was left over in my bowels, and luckily it all happened. What we are hoping to do now with No More Heroes 3 is probably to digest everything we eat and then purge absolutely everything in our guts, just like diarrhea!"