Odds released by bookmakers Victor Chandler give Uncharted 2 6/4 with Call of Duty: Modern Warfare 2 in second favourite for the award at 9/4. The GAME award is the only BAFTA prize to be voted on by the public.
The other contenders are Batman Arkham Asylum, Assassin's Creed II, Wii Sports Resort and Legend of Zelda Spirit Tracks.
The GAME British Academy Video Game Awards will take place in London on 19th March.
Peter Laverick, marketing director of Victor Chandler, said of the odds:
"Unchartered 2 is a very strong favourite at 6/4 and we've already taken numerous four figure bets on it, for those looking for an outside bet we have seen support for FIFA 10 at 33/1. It's always tricky offering odds on a public vote so we'll be keeping a close eye on the money rolling in."Neil Ashurst, head of UK PR for GAME said:
"We've already seen huge interest from all over the world in this year's award with people campaigning online for their favourite title. As the deadline looms closer, I would urge all gamers to cast their vote at www.baftagameaward.com and make sure their voice is heard."